Andrew Nembhard scored 23 points and Tyrese Haliburton had 22 points, 13 assists and three blocked shots as the Indiana Pacers pulled away for a 121-112 road win over the top-seeded Cleveland Cavaliers in Game 1 of the Eastern Conference semifinals on Sunday night.

Pascal Siakam and Aaron Nesmith each scored 17 points, and Myles Turner had 13 points, 11 rebounds, three steals and two blocks for fourth-seeded Indiana, which handed the Cavaliers their first loss of the postseason.

Haliburton’s 3-pointer with 6:21 left put the Pacers ahead for good at 104-102.

Ty Jerome had 21 points and eight assists, and Evan Mobley posted 20 points and 10 rebounds for the Cavaliers. Cleveland played its third straight game without All-Star guard Darius Garland, who sprained his left big toe against the Miami Heat on April 23.

Cleveland was sluggish from the tip in its first game in six days, falling behind by 11 in the first quarter and 12 in the second.

Nesmith had three 3-pointers in the first five minutes of the third period, extending Indiana’s lead to 80-68. The Cavaliers responded moments later with a 13-0 run fueled by nine points from Mitchell. Turner’s 3-pointer at the horn put the Pacers back in front 92-90.

Indiana’s advantage swelled to 45-33 on Bennedict Mathurin’s hoop early in the second, but the Cavaliers closed within 64-58 at intermission. Mitchell had 15 points on 7-of-16 shooting in the half, while Siakam scored 13 and Nembhard had 12 for the Pacers.

Cleveland completed the only sweep in the East on April 28 in Miami, setting a league record with a 122-point combined margin of victory in a four-game sweep. The Cavaliers are competing in back-to-back conference semifinals for the first time since 2017-2018.

Fourth-seeded Indiana eliminated Milwaukee in five games in the opening round. The Pacers reached the 2024 East final, losing to eventual champion Boston in four games.